About   Help   FAQ
Targeted Allele Detail
Symbol: Kcnq2tm1.1Naas
Name: potassium voltage-gated channel, subfamily Q, member 2; targeted mutation 1.1, Nanda A Singh
MGI ID: MGI:4397592
Synonyms: Kcnq2A306T
Gene: Kcnq2  Location: Chr2:181075579-181135300 bp, - strand  Genetic Position: Chr2, 103.57 cM, cytoband H3-4
Germline Transmission:  Earliest citation of germline transmission: J:154582
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA self-excising neo cassette was inserted upsteam of a modified exon 6 containing nucleotide substitutions that result in the amino acid substitution of threonine for alanine at position 306 (A306T). The neo cassette subsequently removes itself leaving a single loxP site. (J:154582)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq2 Mutation:  25 strains or lines available
Original:  J:154582 Singh NA, et al., Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15;586(14):3405-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory