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Targeted Allele Detail
Symbol: Kcnq2tm1.1Naas
Name: potassium voltage-gated channel, subfamily Q, member 2; targeted mutation 1.1, Nanda A Singh
MGI ID: MGI:4397592
Synonyms: Kcnq2A306T
Gene: Kcnq2  Location: Chr2:181075579-181135300 bp, - strand  Genetic Position: Chr2, 103.57 cM, cytoband H3-4
Germline Transmission:  Earliest citation of germline transmission: J:154582
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA self-excising neo cassette was inserted upsteam of a modified exon 6 containing nucleotide substitutions that result in the amino acid substitution of threonine for alanine at position 306 (A306T). The neo cassette subsequently removes itself leaving a single loxP site. (J:154582)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq2 Mutation:  16 strains or lines available
Original:  J:154582 Singh NA, et al., Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15;586(14):3405-23
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory