Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1.1Naas mutation
(0 available);
any
Kcnq2 mutation
(47 available)
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mortality/aging
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• some mice die between P23 and P32
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nervous system
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• between P24 and P52, mice exhibit at least one tonic-clonic seizure of the fore- or hindlimbs unlike wild-type mice
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growth/size/body
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• at weaning, mice are 22% to 46% smaller than wild-type mice
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behavior/neurological
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• between P24 and P52, mice exhibit at least one tonic-clonic seizure of the fore- or hindlimbs unlike wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1.1Naas mutation
(0 available);
any
Kcnq2 mutation
(47 available)
|
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mortality/aging
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• most mice die between P16 and P30
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• most mice die between P16 and P30
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• fewer than expected mice were born
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nervous system
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• mice exhibit rapid onset of spontaneous seizures that result in death
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growth/size/body
behavior/neurological
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• mice exhibit rapid onset of spontaneous seizures that result in death
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1.1Naas mutation
(0 available);
any
Kcnq2 mutation
(47 available)
|
|
|
mortality/aging
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• fewer than expected mice were born
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nervous system
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• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice
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• CA1 neurons exhibit decreased M-type potassium ion current amplitude and density compared with wild-type neurons
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behavior/neurological
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• mice exhibit spontaneous seizures with frequent generalized interictal cortical discharges, forepaw grooming, and clonic twitching unlike wild-type mice
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Allelic Composition |
Kcnq2tm1.1Naas/Kcnq2+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnq2tm1.1Naas mutation
(0 available);
any
Kcnq2 mutation
(47 available)
|
|
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behavior/neurological
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• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice
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nervous system
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• mice exhibit decreased threshold to convulsive current at which 50% of mice exhibit tonic hindlimb extension seizure compared with wild-type mice
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