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Targeted Allele Detail
Symbol: Sort1tm1Camo
Name: sortilin 1; targeted mutation 1, Carlos R Morales
MGI ID: MGI:4397584
Synonyms: sortilin-
Gene: Sort1  Location: Chr3:108284082-108361511 bp, + strand  Genetic Position: Chr3, 46.9 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:154468
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe segement between exon 2 and intron 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, lung, and testis extracts. (J:154468)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sort1 Mutation:  8 strains or lines available
Original:  J:154468 Zeng J, et al., The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. Exp Cell Res. 2009 Nov 1;315(18):3112-24
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory