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Parvatm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Parvatm1Ref
Name: parvin, alpha; targeted mutation 1, Reinhard Fassler
MGI ID: MGI:4368017
Synonyms: alpha-pv-
Gene: Parva  Location: Chr7:112427706-112591688 bp, + strand  Genetic Position: Chr7, 58.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154437
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-lacZ gene and neo cassette were inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on muscle cell extracts. (J:154437)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Parva Mutation:  14 strains or lines available
References
Original:  J:154437 Montanez E, et al., Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 2009 Oct 21;28(20):3132-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory