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Nfkb1tm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Nfkb1tm1a(KOMP)Wtsi
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363738
Gene: Nfkb1  Location: Chr3:135584655-135691547 bp, - strand  Genetic Position: Chr3, 62.82 cM
Mutation
origin
Mutant Cell Lines:  EPD0033_4_A01, EPD0033_4_B02, EPD0033_4_D01, EPD0033_4_D02, EPD0033_4_E01, EPD0033_4_E02, EPD0033_4_F01, EPD0033_4_F02, EPD0033_4_G01, EPD0033_4_G02, EPD0033_4_H01
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 135663474 of Chromosome 3 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 135662651. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Nfkb1 Mutation:  91 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory