Phenotypes associated with this allele

• Allele Symbol: Nfkb1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363738
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkb1^tm1a(KOMP)Wtsi/Nfkb1^tm1a(KOMP)Wtsi	B6JTyr;B6N-Nfkb1^tm1a(KOMP)Wtsi/Wtsi	MGI:5781683
hm2	Nfkb1^tm1a(KOMP)Wtsi/Nfkb1^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790971

Genotype
MGI:5781683

hm1

• Allelic Composition: Nfkb1^{tm1a(KOMP)Wtsi}/Nfkb1^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Nfkb1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_4_D01

Data Sources

IMPC Data for Nfkb1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:175295 )

♂

IMPC - WTSI

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:175295 )

♂

IMPC - WTSI

increased leukocyte cell number ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

homeostasis/metabolism

increased circulating free fatty acids level ( J:175295 )

IMPC - WTSI

decreased circulating sodium level ( J:165965 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:165965 )

♀

IMPC - WTSI

decreased circulating amylase level ( J:175295 )

IMPC - WTSI

immune system

increased leukocyte cell number ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

behavior/neurological

decreased thermal nociceptive threshold ( J:165965 )

♀

IMPC - WTSI

increased thermal nociceptive threshold ( J:165965 )

♂

IMPC - WTSI

integument

abnormal skin condition ( J:165965 )

♀

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:165965 )

♀

IMPC - WTSI

Genotype
MGI:5790971

hm2

• Allelic Composition: Nfkb1^{tm1a(KOMP)Wtsi}/Nfkb1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0033_4_D01

hematopoietic system

decreased NK cell number ( J:213427 )

decreased regulatory T cell number ( J:213427 )

increased leukocyte cell number ( J:213427 )

decreased IgA level ( J:213427 )

decreased IgG1 level ( J:213427 )

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:213427 )

decreased respiratory quotient ( J:213427 )

immune system

decreased NK cell number ( J:213427 )

decreased regulatory T cell number ( J:213427 )

increased leukocyte cell number ( J:213427 )

decreased IgA level ( J:213427 )

decreased IgG1 level ( J:213427 )

lymphoid hyperplasia ( J:213427 )

increased susceptibility to bacterial infection ( J:213427 )