Hnrnpk^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Hnrnpk^{tm1(KOMP)Wtsi}
• Name: heterogeneous nuclear ribonucleoprotein K; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4363684
• Gene: Hnrnpk Location: Chr13:58538956-58551157 bp, - strand Genetic Position: Chr13, 31.04 cM, cytoband B2
• Alliance: Hnrnpk^{tm1(KOMP)Wtsi} page
• IMPC: Hnrnpk gene page

Mutation origin

• Mutant Cell Lines: EPD0323_2_B02, EPD0323_2_C03, EPD0323_2_D01, EPD0323_2_E02
• Germline Transmission: Earliest citation of germline transmission: J:225947
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3186 starting at position 58544639 and ending at position 58547825 of Chromosome 13 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Tumor Data

List all tumor models in MMHCdb carrying Hnrnpk^{tm1(KOMP)Wtsi}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Hnrnpk Mutation: 39 strains or lines available

Notes

Cell line EPD0323_2_B02 was successfully used to make chimeric mice. Germline transmission was accomplished. J:225947

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 4 reference(s)