About   Help   FAQ
Panx1tm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Panx1tm1a(KOMP)Wtsi
Name: pannexin 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363250
Gene: Panx1  Location: Chr9:15005785-15045478 bp, - strand  Genetic Position: Chr9, 4.52 cM
Mutation
origin
Mutant Cell Lines:  EPD0309_3_B01, EPD0309_3_B03, EPD0309_3_C02, EPD0309_3_D03, EPD0309_3_E01, EPD0309_3_F01
Germline Transmission:  Earliest citation of germline transmission: J:175396
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 15010456 of Chromosome 9 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 15009768. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534, J:175396, J:177671)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 3 lines available
Carrying any Panx1 Mutation:  4 strains or lines available
Notes
J:187675 used mice created from EPD0309_3_B01 J:177671 used mice created from EPD0309_3_B01
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2020
MGI 6.15
The Jackson Laboratory