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Smyd3tm2a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Smyd3tm2a(KOMP)Wtsi
Name: SET and MYND domain containing 3; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363150
Gene: Smyd3  Location: Chr1:178951960-179518041 bp, - strand  Genetic Position: Chr1, 83.48 cM, cytoband H3
Mutation
origin
Mutant Cell Lines:  EPD0013_1_A07, EPD0013_1_B07, EPD0013_1_C07, EPD0013_1_E07, EPD0013_1_G07, EPD0013_1_H07, EPD0022_2_A04, EPD0022_2_B04, EPD0022_2_B05, EPD0022_2_C04, EPD0022_2_C06, EPD0022_2_D04, EPD0022_2_D05, EPD0022_2_F04, EPD0022_2_F06, EPD0022_2_G04, EPD0022_2_G05, EPD0022_2_G06, EPD0022_2_H04, EPD0022_2_H05
Germline Transmission:  Earliest citation of germline transmission: J:213427
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 179423965 of Chromosome 1 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 179423016. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smyd3 Mutation:  29 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory