About   Help   FAQ
Mysm1tm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Mysm1tm1a(KOMP)Wtsi
Name: myb-like, SWIRM and MPN domains 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362924
Synonyms: Mysm1tm1a, Mysm1tm1a(deltaMP)Wtsi
Gene: Mysm1  Location: Chr4:94942040-94979100 bp, - strand  Genetic Position: Chr4, 43.34 cM
Mutation
origin
Mutant Cell Lines:  EPD0019_1_A04, EPD0019_1_A05, EPD0019_1_A06, EPD0019_1_B06, EPD0019_1_C04, EPD0019_1_D04, EPD0019_1_D05, EPD0019_1_F04, EPD0019_1_F05, EPD0019_1_F06, EPD0019_1_G05, EPD0019_1_H04, EPD0019_1_H05, EPD0019_1_H06 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:179287
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st0
 
Mutation detailsThe L1L2_st0 cassette was inserted at position 94973448 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 94972656. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:148605, J:173534)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Mysm1 Mutation:  20 strains or lines available
Notes
EPD0019_1_A04 ES cells were used to generate the mice used in J:179287.
EPD0019_1_A05 ES cells were used to generate the mice used in J:181727.
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory