About   Help   FAQ
Targeted Allele Detail
Symbol: Akap9tm1a(KOMP)Wtsi
Name: A kinase (PRKA) anchor protein (yotiao) 9; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362642
Synonyms: Akap9Gt
Gene: Akap9  Location: Chr5:3977410-4130204 bp, + strand  Genetic Position: Chr5, 2.26 cM, cytoband A2
Mutant Cell Lines:  EPD0033_5_A02, EPD0033_5_A03, EPD0033_5_B01, EPD0033_5_B02, EPD0033_5_B03, EPD0033_5_C01, EPD0033_5_C02, EPD0033_5_C03, EPD0033_5_D01, EPD0033_5_D02, EPD0033_5_D03, EPD0033_5_E02, EPD0033_5_E03, EPD0033_5_F01, EPD0033_5_F02, EPD0033_5_G02, EPD0033_5_G03, EPD0033_5_H01, EPD0033_5_H02, EPD0033_5_H03
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 4018123 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 4019078. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Akap9 Mutation:  115 strains or lines available
Cell line EPD0033_5_D02 was successfully used to make chimeric mice. Germline transmission was accomplished. J:198499
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory