Phenotypes associated with this allele

• Allele Symbol: Akap9^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362642
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap9^tm1a(KOMP)Wtsi/Akap9^tm1a(KOMP)Wtsi	B6JTyr;B6N-Akap9^tm1a(KOMP)Wtsi/Wtsi	MGI:5781563
ht2	Akap9^tm1a(KOMP)Wtsi/Akap9^+	B6JTyr;B6N-Akap9^tm1a(KOMP)Wtsi/Wtsi	MGI:5781562
ht3	Akap9^tm1a(KOMP)Wtsi/Akap9^+	involves: C57BL/6 * C57BL/6N	MGI:5790839

Genotype
MGI:5781563

hm1

• Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_5_D02

Data Sources

IMPC Data for Akap9

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

skeleton

decreased lumbar vertebrae number ( J:175295 )

♀

IMPC - WTSI

Genotype
MGI:5781562

ht2

• Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9⁺
• Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_5_D02

Data Sources

IMPC Data for Akap9

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

abnormal head morphology ( J:175295 )

♂

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:175295 )

♂

IMPC - WTSI

increased circulating fructosamine level ( J:175295 )

♀

IMPC - WTSI

decreased circulating cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating LDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating calcium level ( J:175295 )

IMPC - WTSI

decreased circulating serum albumin level ( J:175295 )

IMPC - WTSI

decreased circulating total protein level ( J:175295 )

IMPC - WTSI

Genotype
MGI:5790839

ht3

• Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0033_5_D02

adipose tissue

decreased total body fat amount ( J:213427 )

decreased percent body fat/body weight ( J:213427 )

craniofacial

abnormal tooth morphology ( J:213427 )

growth/size/body

abnormal tooth morphology ( J:213427 )

decreased lean body mass ( J:213427 )

decreased body weight ( J:213427 )

hematopoietic system

decreased B cell number ( J:213427 )

decreased mature B cell number ( J:213427 )

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

homeostasis/metabolism

decreased circulating glucose level ( J:213427 )

decreased circulating cholesterol level ( J:213427 )

decreased circulating HDL cholesterol level ( J:213427 )

decreased circulating LDL cholesterol level ( J:213427 )

increased circulating alkaline phosphatase level ( J:213427 )

decreased circulating serum albumin level ( J:213427 )

decreased circulating total protein level ( J:213427 )

increased energy expenditure ( J:213427 )

increased carbon dioxide production ( J:213427 )

increased oxygen consumption ( J:213427 )

immune system

decreased B cell number ( J:213427 )

decreased mature B cell number ( J:213427 )

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

mortality/aging

lethality, incomplete penetrance ( J:213427 )

skeleton

abnormal tooth morphology ( J:213427 )

abnormal pelvic girdle bone morphology ( J:213427 )