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Tg(Pomc-cre)1Lowl
Transgene Detail
Nomenclature
Symbol: Tg(Pomc-cre)1Lowl
Name: transgene insertion 1, Bradford B Lowell
MGI ID: MGI:4362028
Synonyms: Pomc-cre, Pomc-Cre(BAC2), Tg(Pomc-cre)1Stl
Transgene: Tg(Pomc-cre)1Lowl  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA Pomc (pro-opiomelanocortin-alpha) (bacterial artificial chromosome; RPCI22-372J15) was used to generate mice expressing cre under the control of the Pomc promoter. The cre recombinase cDNA was inserted via homologous recombination into the first ATG transcription start site, ablating the first 30bp of the POMC coding sequence. This transgenic vector was introduced to FVB-derived embryos. (J:106354, J:122763)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pomc     Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:122763 McHugh TJ, et al., Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 2007 Jul 6;317(5834):94-9
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory