Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Pomc-cre)1Lowl transgene insertion 1, Bradford B Lowell MGI:4362028 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal body weight and fat weight even at 16 weeks of age
• mice fed a high-fat diet starting at 6 weeks of age and maintained for 4 weeks do not develop obesity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no obvious defects in mossy fiber projections or CA3 layering are seen in P55 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• population responses recordings from the stimulated perforant path in the dentate hilus are not different from controls at 20-24 weeks
• paired-pulse facilitation is normal
• long term potentiation in area CA1 after Schaffer commissural input stimulation in CA3
• hippocampal memory and discrimination is normal in mutants (measured by acquisition of contextual fear conditioning)
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• theta-burst stimulation of the perforant path (PP) did not evoke potentiation (plasticity) of synapses of the PP-GC (dentate gyrus granule cells)
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| N |
• open field activity is not different from controls
• no differences are seen in feeding behavior or body weights compared to controls
• spatial learning in Morris water maze test is normal
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• mice show impaired acquisition of a discrimination task compared to controls; deficit is limited to early days of training, but is comparable to controls after extended training
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal contextual fear memory, in contrast to mice carrying the Drd1atm2.1 allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit impaired fear memory in 24 hour contextual memory test at multiple time points as compared to control, however, mice exhibit normal cued fear conditioning during tone presentation and have a normal short term memory fear response
• mice exhibit similar fear response between two similar but different contexts, in contrast, controls freeze more in the original (shock) context than in the similar context
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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