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Cdh23tm1.1Ugds
Targeted Allele Detail
Nomenclature
Symbol: Cdh23tm1.1Ugds
Name: cadherin 23 (otocadherin); targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
MGI ID: MGI:4361286
Synonyms: Cdh23fl
Gene: Cdh23  Location: Chr10:60302748-60696490 bp, - strand  Genetic Position: Chr10, 30.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158897
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 62 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 68. Flp mediated recombination removed the neo cassette leaving exons 62 through 68 floxed. (J:158897)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh23 Mutation:  81 strains or lines available
References
Original:  J:158897 Etournay R, et al., Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape. Development. 2010 Apr;137(8):1373-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory