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Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Transgene Detail
Nomenclature
Symbol: Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Name: transgene insertion 2, Jacqueline Hecht
MGI ID: MGI:4361028
Synonyms: MT-COMP, Tg(Col2a1-rtTA,TRE-COMP*)2Jath
Transgene: Tg(Col2a1-rtTA,tetO-COMP*)2Jath  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Transactivator)
Mutation:    Insertion
 
Tg(Col2a1-rtTA,tetO-COMP*)2Jath expresses 1 gene
 
Mutation detailsBigenic mice contain a rtTA driven by the mouse Col2a1 promoter and human COMP, with the deletion del469D found in patients with pseudoachondroplasia, driven by the tetO promoter. Three line were generated (no line names given). (J:152756)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:152756 Posey KL, et al., An Inducible Cartilage Oligomeric Matrix Protein Mouse Model Recapitulates Human Pseudoachondroplasia Phenotype. Am J Pathol. 2009 Sep 17;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory