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Atn1tm1Rexu
Targeted Allele Detail
Nomenclature
Symbol: Atn1tm1Rexu
Name: atrophin 1; targeted mutation 1, Rener Xu
MGI ID: MGI:4360645
Synonyms: Atn1t
Gene: Atn1  Location: Chr6:124739189-124756524 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152709
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-Neo cassette was inserted into exon 5 by homologous recombination to introduce a premature "TAG" stop codon and produce a truncated protein of 416 amino acids with an intact N-terminus but lacking both the poly-Q stretch and following C-terminal peptides. Protein was detected at a level similar to that of the wild-type protein (1,175 amino acids) in brain samples. (J:152709)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atn1 Mutation:  20 strains or lines available
References
Original:  J:152709 Yu J, et al., C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. Dev Dyn. 2009 Aug 13;238(10):2471-2478
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory