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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atn1tm1Rexu
targeted mutation 1, Rener Xu
MGI:4360645
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atn1tm1Rexu/Atn1tm1Rexu involves: C57BL/6 MGI:4360683
cx2
 		Atn1tm1Rexu/Atn1tm1Rexu
Tg(Eno2-ATN1)3Tx/0 		involves: C57BL/6 * SJL/J MGI:4360689


Genotype
MGI:4360683
hm1
Allelic
Composition		 Atn1tm1Rexu/Atn1tm1Rexu
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atn1tm1Rexu mutation (0 available); any Atn1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:152709 )
• shorter average life span (90 weeks)
postnatal lethality, incomplete penetrance ( J:152709 )
• viable at birth with expected Mendelian ratios
• approximately 30% die before weaning

growth/size/body
decreased body weight ( J:152709 )
• newborn have normal body weight
• approximately 20% lighter by the age of weaning
• low body weight persists through puberty and adulthood
• can not be rescued by a neuron specific wild-type human Atrophin-1 transgene Tg(Eno2-ATN1)1Tx

behavior/neurological
decreased food intake ( J:152709 )
• adult mice consume less food
• normal rotarod test results

reproductive system
small testis ( J:152709 )
• in 5 of 8 mice
• apoptotic cells frequently found
• degeneration in aged mice
abnormal sperm number ( J:152709 )
• low sperm counts in testes and epididymis
• apoptosis frequently observed in aged mutant testis
reduced male fertility ( J:152709 )
• gradually lose fertility and became sterile at the age around eight months

nervous system
nervous system phenotype ( J:152709 )
N
• normal brain structure and morphology
• no neurodegeneration

endocrine/exocrine glands
small testis ( J:152709 )
• in 5 of 8 mice
• apoptotic cells frequently found
• degeneration in aged mice




Genotype
MGI:4360689
cx2
Allelic
Composition		 Atn1tm1Rexu/Atn1tm1Rexu
Tg(Eno2-ATN1)3Tx/0
Genetic
Background		 involves: C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atn1tm1Rexu mutation (0 available); any Atn1 mutation (49 available)
Tg(Eno2-ATN1)3Tx mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory