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Tbpl2tm1.1Lzt
Targeted Allele Detail
Nomenclature
Symbol: Tbpl2tm1.1Lzt
Name: TATA box binding protein like 2; targeted mutation 1.1, Laszlo Tora
MGI ID: MGI:4360523
Synonyms: Tbp2-
Gene: Tbpl2  Location: Chr2:23961733-23986607 bp, - strand  Genetic Position: Chr2, 16.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152449
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination removed exon 4. The absence of protein expression was confirmed by western blot analysis on ovary extracts. (J:152449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbpl2 Mutation:  17 strains or lines available
References
Original:  J:152449 Gazdag E, et al., TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev. 2009 Sep 15;23(18):2210-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory