Phenotypes associated with this allele

• Allele Symbol: Tbpl2^tm1.1Lzt
• Allele Name: targeted mutation 1.1, Laszlo Tora
• Allele ID: MGI:4360523
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbpl2^tm1.1Lzt/Tbpl2^tm1.1Lzt	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:4360539

Genotype
MGI:4360539

hm1

• Allelic Composition: Tbpl2^tm1.1Lzt/Tbpl2^tm1.1Lzt
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oocyte morphology ( J:152449 )

♀ • at 6 weeks, abnormal oocyte development becomes more pronounced

♀ • oocytes exhibit disorganized chromatin unlike wild-type cells

absent zona pellucida ( J:152449 )

♀

oocyte degeneration ( J:152449 )

♀

abnormal granulosa cell apoptosis ( J:152449 )

♀ • at 2 weeks, granulosa cells fail to undergo apoptosis as in wild-type mice

growth/size/body

ovarian follicular cyst ( J:152449 )

♀ • cyct-containing structures are found in the follicles

reproductive system

abnormal oocyte morphology ( J:152449 )

♀ • at 6 weeks, abnormal oocyte development becomes more pronounced

♀ • oocytes exhibit disorganized chromatin unlike wild-type cells

absent zona pellucida ( J:152449 )

♀

oocyte degeneration ( J:152449 )

♀

abnormal granulosa cell apoptosis ( J:152449 )

♀ • at 2 weeks, granulosa cells fail to undergo apoptosis as in wild-type mice

abnormal ovarian follicle number ( J:152449 )

♀ • at 6 weeks, follicles are gradually depleted unlike in wild-type mice

absent mature ovarian follicles ( J:152449 )

♀ • ovaries lack mature ovarian follicles unlike in wild-type mice

decreased primary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer primary follicles compared to in wild-type mice

increased primordial ovarian follicle number ( J:152449 )

♀ • mice exhibit an increase in the number of immature follicles compared to in wild-type mice

decreased secondary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer secondary follicles compared to in wild-type mice

decreased tertiary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer antral follicles compared to in wild-type mice

impaired ovarian folliculogenesis ( J:152449 )

♀ • before or during secondary follicle formation

ovarian follicular cyst ( J:152449 )

♀ • cyct-containing structures are found in the follicles

small ovary ( J:152449 )

♀ • at 6 weeks

failure of superovulation ( J:152449 )

♀ • mice fail to ovulate when treated with hormones unlike similarly treated wild-type mice

female infertility ( J:152449 )

♀

endocrine/exocrine glands

abnormal granulosa cell apoptosis ( J:152449 )

♀ • at 2 weeks, granulosa cells fail to undergo apoptosis as in wild-type mice

abnormal ovarian follicle number ( J:152449 )

♀ • at 6 weeks, follicles are gradually depleted unlike in wild-type mice

absent mature ovarian follicles ( J:152449 )

♀ • ovaries lack mature ovarian follicles unlike in wild-type mice

decreased primary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer primary follicles compared to in wild-type mice

increased primordial ovarian follicle number ( J:152449 )

♀ • mice exhibit an increase in the number of immature follicles compared to in wild-type mice

decreased secondary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer secondary follicles compared to in wild-type mice

decreased tertiary ovarian follicle number ( J:152449 )

♀ • ovaries contain fewer antral follicles compared to in wild-type mice

impaired ovarian folliculogenesis ( J:152449 )

♀ • before or during secondary follicle formation

ovarian follicular cyst ( J:152449 )

♀ • cyct-containing structures are found in the follicles

small ovary ( J:152449 )

♀ • at 6 weeks