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Dlx6os1tm1.1Jhdk
Targeted Allele Detail
Summary
Symbol: Dlx6os1tm1.1Jhdk
Name: distal-less homeobox 6, opposite strand 1; targeted mutation 1.1, Jhumku D Kohtz
MGI ID: MGI:4360101
Synonyms: Evf2TS
Gene: Dlx6os1  Location: Chr6:6820543-6871627 bp, - strand  Genetic Position: Chr6, 2.68 cM
Alliance: Dlx6os1tm1.1Jhdk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152532
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsA STOP cassette (triple polyadenylation signal sequences) was inserted into exon 1, truncating Dlx6os1 splice variant Evf2 from 3.7 kb to 101 bp without affecting the transcription of splice variant Evf1. RT-PCR confirmed that the expression of Dlx5 and Dlx6 are increased. A loxP site flanked neomycin resistance gene cassette was removed by cre-mediated recombination. (J:152532)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 80 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dlx6os1 Mutation:  3 strains or lines available
References
Original:  J:152532 Bond AM, et al., Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. Nat Neurosci. 2009 Aug;12(8):1020-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory