Phenotypes associated with this allele

• Allele Symbol: Dlx6os1^tm1.1Jhdk
• Allele Name: targeted mutation 1.1, Jhumku D Kohtz
• Allele ID: MGI:4360101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlx6os1^tm1.1Jhdk/Dlx6os1^tm1.1Jhdk	involves: 129 * C57BL/6 * FVB/N	MGI:4360107

Genotype
MGI:4360107

hm1

• Allelic Composition: Dlx6os1^tm1.1Jhdk/Dlx6os1^tm1.1Jhdk
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

loss of GABAergic neurons ( J:152532 )

• young mice exhibit a loss of GABAergic interneurons compared to in wild-type mice

• however, older mice exhibit normal numbers of GABAergic interneurons

abnormal inhibitory postsynaptic currents ( J:152532 )

• adult and old mice exhibit a 42% and 38% reduction, respectively, of spontaneous inhibitory postsynaptic current (sIPSC) frequencies in CA1 pyramidal cells compared to in wild-type mice

• however, sIPSC amplitudes are normal

• evoked inhibitory postsynaptic currents are smaller than in wild-type mice

decreased miniature inhibitory postsynaptic current frequency ( J:152532 )

• adult and old mice exhibit a reduction in frequencies of miniature inhibitory postsynaptic currents (mIPSC) compared with wild-type mice

• however, mIPSC amplitudes are normal