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Transgene Detail
Symbol: Tg(Myh6-SOD2,Tyr)3Pne
Name: transgene insertion 3, Paul N Epstein
MGI ID: MGI:4360100
Synonyms: MnSOD3, MS, MySOD
Transgene: Tg(Myh6-SOD2,Tyr)3Pne  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6-SOD2,Tyr)3Pne expresses 1 gene
Mutation detailsA transgenic construct containing the human, superoxide dismutase 2, mitochondrial gene under the control of the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha, promoter and a polyadenylation sequence (550-bp fragment of the rat insulin II gene) was co-injected with a tyrosinase minigene where tyrosinase is under the control of the tyrosinase promoter, commonly referred to as TyBs into fertilized FVB mouse eggs. Founder line 3 was subsequently established. (J:106815, J:152215)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:106815 Mantena SK, et al., Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J Nutr. 2005 Dec;135(12):2871-7
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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