Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-SOD2,Tyr)3Pne
• Allele Name: transgene insertion 3, Paul N Epstein
• Allele ID: MGI:4360100
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Cryaa-TAg,Ins2-CALM1)26Ove/0 Tg(Myh6-SOD2,Tyr)3Pne/0	FVB-Tg(Cryaa-TAg,Ins2-CALM1)26Ove Tg(Myh6-SOD2,Tyr)3Pne	MGI:4360116
tg2	Tg(Myh6-SOD2,Tyr)3Pne/0	FVB-Tg(Myh6-SOD2,Tyr)3Pne	MGI:4360114

Genotype
MGI:4360116

cx1

• Allelic Composition: Tg(Cryaa-TAg,Ins2-CALM1)26Ove/0; Tg(Myh6-SOD2,Tyr)3Pne/0
• Genetic Background: FVB-Tg(Cryaa-TAg,Ins2-CALM1)26Ove Tg(Myh6-SOD2,Tyr)3Pne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:106815 )

N • no diabetes-induced increases in mitochondrial area, number, protein, or DNA content are observed

homeostasis/metabolism

hyperglycemia ( J:106815 )

• nonfaster hyperglycemia usually exceeds >600 mg/dl

cardiovascular system

cardiovascular system phenotype ( J:106815 )

N • no damage is seen in the heart in contrast to single transgenic Tg(Ins2-CALM1)26Ove mice

N • contractile parameters are normalized in double transgenic hearts

Genotype
MGI:4360114

tg2

• Allelic Composition: Tg(Myh6-SOD2,Tyr)3Pne/0
• Genetic Background: FVB-Tg(Myh6-SOD2,Tyr)3Pne

cellular

abnormal cell physiology ( J:106815 )

• isolated cardiomyocytes exhibit enhanced reactive oxygen species (ROS) scavenging after exposure to superoxide or hydrogen peroxide, compared to wild-type cells; levels of intracellular ROS are significantly reduced

cardiovascular system

cardiovascular system phenotype ( J:106815 )

N • cardiac ultrastructure is indistinguishable from controls