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Gpx5tm1115.2Arte
Targeted Allele Detail
Nomenclature
Symbol: Gpx5tm1115.2Arte
Name: glutathione peroxidase 5; targeted mutation 1115.2, TaconicArtemis
MGI ID: MGI:4359923
Synonyms: Gpx5tm1115_.2Arte
Gene: Gpx5  Location: Chr13:21286429-21292727 bp, - strand  Genetic Position: Chr13, 7.73 cM, cytoband A2-A4
Cauda epididymidis-retrieved spermatozoa from Gpx5tm1115.2Arte/Gpx5tm1115.2Arte mice suffer oxidative damage

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152563
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on caput epididymidis extracts. (J:152563)
Generation of the Gpx5tm1115.1Arte and Gpx5tm1115.2Arte alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpx5 Mutation:  0 strains or lines available
References
Original:  J:152563 Chabory E, et al., Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest. 2009 Jul;119(7):2074-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory