Pik3cb^tm1.1Ehi
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1.1Ehi
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1, Emilio Hirsch
• MGI ID: MGI:4358053
• Synonyms: PIK3CB^805R, Pik3cb^K805, PIK3CB^K805R, PIKbeta^KD
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1.1Ehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152332
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 5 was replaced with one in which a point mutation results in an amino acid substitution of arginine for lysine at position 805 (K805R). A floxed neo cassette was used for selection purposes and removed by germ line, cre-mediated recombination. The predicted protein is expected to be a kinase dead version. (J:152332)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 151 strains or lines available

References

• Original: J:152332 Ciraolo E, et al., Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal. 2008;1(36):ra3
• All: 9 reference(s)