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Galnt3tm1Mjec
Targeted Allele Detail
Nomenclature
Symbol: Galnt3tm1Mjec
Name: polypeptide N-acetylgalactosaminyltransferase 3; targeted mutation 1, Michael J Econs
MGI ID: MGI:4355571
Gene: Galnt3  Location: Chr2:66082766-66124994 bp, - strand  Genetic Position: Chr2, 38.99 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151805
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with an loxP-flanked neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:151805)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Galnt3 Mutation:  19 strains or lines available
References
Original:  J:151805 Ichikawa S, et al., Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology. 2009 Jun;150(6):2543-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory