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Targeted Allele Detail
Symbol: Dtx1tm1.2Mzl
Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1.2, Ming-Zong Lai
MGI ID: MGI:4355029
Gene: Dtx1  Location: Chr5:120680202-120711927 bp, - strand  Genetic Position: Chr5, 60.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:151605
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA Frt-flanked neomycin cassette and a loxP site were placed downstream of exon 3. An additional loxP site was placed upstream of exon 3. Exon 3 and the neomycin cassette were deleted from the germline by crossing founder mice with cre-transgenic mice. Protein was undetectable in homozygote splenic lymphocytes as determined by immunoblot analysis. (J:151605)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtx1 Mutation:  25 strains or lines available
Original:  J:151605 Hsiao HW, et al., Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. Immunity. 2009 Jul 17;31(1):72-83
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory