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Dtx1tm1.2Mzl
Targeted Allele Detail
Summary
Symbol: Dtx1tm1.2Mzl
Name: deltex 1, E3 ubiquitin ligase; targeted mutation 1.2, Ming-Zong Lai
MGI ID: MGI:4355029
Gene: Dtx1  Location: Chr5:120818267-120849992 bp, - strand  Genetic Position: Chr5, 60.64 cM
Alliance: Dtx1tm1.2Mzl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151605
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA Frt-flanked neomycin cassette and a loxP site were placed downstream of exon 3. An additional loxP site was placed upstream of exon 3. Exon 3 and the neomycin cassette were deleted from the germline by crossing founder mice with cre-transgenic mice. Protein was undetectable in homozygote splenic lymphocytes as determined by immunoblot analysis. (J:151605)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtx1 Mutation:  35 strains or lines available
References
Original:  J:151605 Hsiao HW, et al., Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. Immunity. 2009 Jul 17;31(1):72-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory