Phenotypes associated with this allele

• Allele Symbol: Dtx1^tm1.2Mzl
• Allele Name: targeted mutation 1.2, Ming-Zong Lai
• Allele ID: MGI:4355029
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dtx1^tm1.2Mzl/Dtx1^tm1.2Mzl	B6.129-Dtx1^tm1.2Mzl	MGI:4355048

Genotype
MGI:4355048

hm1

• Allelic Composition: Dtx1^tm1.2Mzl/Dtx1^tm1.2Mzl
• Genetic Background: B6.129-Dtx1^tm1.2Mzl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:151605 )

• mice have mild splenomegaly resulting from increased cell number

abnormal lymphocyte morphology ( J:151605 )

decreased marginal zone B cell number ( J:151605 )

• marginal zone B cell numbers are reduced about 40%

abnormal lymphocyte physiology ( J:151605 )

decreased thymocyte apoptosis ( J:151605 )

• thymocytes have reduced rates of apoptosis in culture

increased B cell proliferation ( J:151605 )

• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal regulatory T cell physiology ( J:151605 )

• there is a modest decrease in TGF-beta1 secretion by regulatory T cells

increased interferon-gamma secretion ( J:151605 )

• IFN-gamma secretion by T cells is doubled after activation compared to controls

increased interleukin-2 secretion ( J:151605 )

• thymocytes and T cells secrete more IL-2 after activation relative to controls

increased interleukin-4 secretion ( J:151605 )

• IL-4 production by T cells is doubled after activation compared to controls

abnormal T cell anergy ( J:151605 )

• T cells are resistant to anergy induced by calcium ionophores or CTLA-4 binding

increased anti-double stranded DNA antibody level ( J:151605 )

• increased levels of anti-DNA antibodies are detected in the sera of mice over 5 months of age

• isotypes of antibodies are predominately IgM, IgG2b and IgG3

increased anti-histone antibody level ( J:151605 )

• increased levels of anti-histone antibodies are detected in the sera of mice over 5 months of age

• isotypes of antibodies are predominately IgM, IgG2b and IgG3

liver inflammation ( J:151605 )

• mononuclear cellular infiltrate is observed in mice after 9 months of age

glomerulonephritis ( J:151605 )

• diffuse immunoglobulin complexes are observed in the glomeruli of mice

lung inflammation ( J:151605 )

• mononuclear cellular infiltrate is observed in mice after 9 months of age

homeostasis/metabolism

decreased transforming growth factor beta level ( J:151605 )

• there is a modest decrease in TGF-beta1 secretion by regulatory T cells

liver/biliary system

liver inflammation ( J:151605 )

• mononuclear cellular infiltrate is observed in mice after 9 months of age

renal/urinary system

glomerulonephritis ( J:151605 )

• diffuse immunoglobulin complexes are observed in the glomeruli of mice

renal glomerular immunoglobulin deposits ( J:151605 )

respiratory system

lung inflammation ( J:151605 )

• mononuclear cellular infiltrate is observed in mice after 9 months of age

hematopoietic system

spleen hyperplasia ( J:151605 )

• mice have mild splenomegaly resulting from increased cell number

abnormal lymphocyte morphology ( J:151605 )

decreased marginal zone B cell number ( J:151605 )

• marginal zone B cell numbers are reduced about 40%

abnormal lymphocyte physiology ( J:151605 )

decreased thymocyte apoptosis ( J:151605 )

• thymocytes have reduced rates of apoptosis in culture

increased B cell proliferation ( J:151605 )

• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

abnormal regulatory T cell physiology ( J:151605 )

• there is a modest decrease in TGF-beta1 secretion by regulatory T cells

cellular

decreased thymocyte apoptosis ( J:151605 )

• thymocytes have reduced rates of apoptosis in culture

increased B cell proliferation ( J:151605 )

• B cell proliferation is enhanced to anti-IgM and anti-CD40 but not to LPS

increased T cell proliferation ( J:151605 )

• T cells hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:151605 )

• thymocytes have reduced rates of apoptosis in culture

abnormal thymocyte activation ( J:151605 )

• thymocytes hyper-proliferate in response to anti-CD3 and anti-CD28 stimulation

growth/size/body

spleen hyperplasia ( J:151605 )

• mice have mild splenomegaly resulting from increased cell number