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Tg(Apoe-Fgf21)1Sakl
Transgene Detail
Nomenclature
Symbol: Tg(Apoe-Fgf21)1Sakl
Name: transgene insertion 1, Steven A Kliewer
MGI ID: MGI:4354167
Synonyms: Tg(Fgf21)
Transgene: Tg(Apoe-Fgf21)1Sakl  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6NCrl
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Apoe-Fgf21)1Sakl expresses 1 gene
 
Mutation detailsThe mouse promoter was used to drive liver-specific expression of the mouse cDNA. Two lines were created (1 and 2) that result in 50-fold, and 150-fold, respectively, higher expression of the transcript compared to in wild-type mice. The two lines exhibit virtually identical changes in fasting serum beta-hydroxybutyrate, triglyceride, total cholesterol, glucose, and insulin concentrations. Line 1 was selected as the representative line. (J:129855)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:129855 Inagaki T, et al., Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21. Cell Metab. 2007 Jun;5(6):415-25
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory