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Themistm1Lov
Targeted Allele Detail
Nomenclature
Symbol: Themistm1Lov
Name: thymocyte selection associated; targeted mutation 1, Paul E Love
MGI ID: MGI:4353254
Synonyms: Themis1-
Gene: Themis  Location: Chr10:28668360-28883818 bp, + strand  Genetic Position: Chr10, 16.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151075
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exon 1 of the locus. Gene inactivation was confirmed by a lack detectable protein product in immunoblot analysis of homozygote thymocyte extracts. (J:151075)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Themis Mutation:  4 strains or lines available
References
Original:  J:151075 Lesourne R, et al., Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009 Aug;10(8):840-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory