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Targeted Allele Detail
Symbol: Pbx1tm3.1Mlc
Name: pre B cell leukemia homeobox 1; targeted mutation 3.1, Michael L Cleary
MGI ID: MGI:4352849
Synonyms: Pbx1f
Gene: Pbx1  Location: Chr1:168119364-168432270 bp, - strand  Genetic Position: Chr1, 75.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:149799
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and an frt flanked selection cassette were inserted downstream of exon 3 via homologous recombination. The selection cassette was then removed by Flp mediated recombination leaving behind a single frt site. (J:149799)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  27 strains or lines available
Original:  J:149799 Ficara F, et al., Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell. 2008 May 8;2(5):484-96
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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