Htra1^{Gt(OST394864)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Htra1^{Gt(OST394864)Lex}
• Name: HtrA serine peptidase 1; gene trap OST394864, Lexicon Genetics
• MGI ID: MGI:4304711
• Gene: Htra1 Location: Chr7:130537933-130587388 bp, + strand Genetic Position: Chr7, 73.2 cM
• Alliance: Htra1^{Gt(OST394864)Lex} page

Mutation origin

• Mutant Cell Line: OST394864
• Germline Transmission: Earliest citation of germline transmission: J:216743
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: Insertion of the trapping vector into the first intron resulted in the generation of a truncated transcript lacking exons 2 through 9. Loss of mRNA expression was demonstrated in various tissues on mRNA level by real-time PCR and protein expression in mouse brain by combined immunoprecipitation/immunoblotting experiments. (J:216743)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST394864	CG647134 ; (MGI Seq Detail)	3' RACE	Chr7:130555072-130555268 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  39 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htra1 Mutation: 50 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)