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Dpcd/PollGt(OST280355)Lex
Gene trapped Allele Detail
Nomenclature
Symbol: Dpcd/PollGt(OST280355)Lex
Name: deleted in primary ciliary dyskinesia; gene trap OST280355, Lexicon Genetics
MGI ID: MGI:4262238
Gene: Dpcd  Location: Chr19:45560590-45578287 bp, + strand  Genetic Position: Chr19, 38.75 cM
Mutation
origin
Mutant Cell Line:  OST280355
Germline Transmission:  Earliest citation of germline transmission: J:171184
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector
 
Mutation detailsGene trap insertion was in intron 1 of Poll and also the promoter region of Dpcd near the transcriptional start site. These two genes overlap, and the gene trap inserted into this overlapping region. By RT-PCR analysis, no endogenous Poll transcript was detected in homozygous tissues. Similary, no endogenous Dpcd transcript was detected in homozygous tissues. (J:171184)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpcd Mutation:  6 strains or lines available
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory