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Targeted Allele Detail
Symbol: Rftn1tm1Ayos
Name: raftlin lipid raft linker 1; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3850829
Synonyms: Raftlin-
Gene: Rftn1  Location: Chr17:49992257-50190674 bp, - strand  Genetic Position: Chr17, 25.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:150299
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe second exon that encodes the first 48 amino acids of the gene product were replaced with a neomycin cassette. Gene inactivation was confirmed by immunoblot analysis on thymus, spleen and bone marrow extracts. (J:150299)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rftn1 Mutation:  7 strains or lines available
Original:  J:150299 Saeki K, et al., A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses. J Immunol. 2009 May 15;182(10):5929-37
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory