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Lcp2tm1.1Wz
Targeted Allele Detail
Nomenclature
Symbol: Lcp2tm1.1Wz
Name: lymphocyte cytosolic protein 2; targeted mutation 1.1, Weiguo Zhang
MGI ID: MGI:3850705
Synonyms: SLP-76m
Gene: Lcp2  Location: Chr11:34046928-34092281 bp, + strand  Genetic Position: Chr11, 19.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:150304
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced most of the coding region in exon 1 and exons 2 and 3. These exons code for the SAM domain and 3 phosphotyrosine motifs. Two amino acids (Ser and Arg) were added to the modified exon 1 to prevent a frame shift. Germ line, cre mediated recombination removed the neo cassette. (J:150304)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lcp2 Mutation:  5 strains or lines available
References
Original:  J:150304 Shen S, et al., The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. Blood. 2009 Jul 2;114(1):74-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory