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Pds5bTg(Wap-ERBB2)229Wzw
Transgenic Allele Detail
Nomenclature
Symbol: Pds5bTg(Wap-ERBB2)229Wzw
Name: PDS5 cohesin associated factor B; transgene insertion 229, Wei-Zen Wei
MGI ID: MGI:3850477
Synonyms: Her-2 Tg, WAP-Her-2
Gene: Pds5b  Location: Chr5:150673739-150810690 bp, + strand  Genetic Position: Chr5, 89.61 cM
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Pds5bTg(Wap-ERBB2)229Wzw expresses 1 gene
 
Mutation detailsA transgenic construct containing a mouse 2.6 kb whey acidic protein (Wap) promoter fused to a human ERBB2 4.4 kb cDNA followed by the bovine growth hormone polyadenylation signal. Line 229 inserted into intron 2 (19 bp upstream of exon 3). (J:132829, J:233887)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pds5b Mutation:  28 strains or lines available
References
Original:  J:132829 Piechocki MP, et al., Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccines. J Immunol. 2003 Dec 1;171(11):5787-94
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory