Myocd^tm1(cre)Jomm
Targeted Allele Detail

Summary

• Symbol: Myocd^tm1(cre)Jomm
• Name: myocardin; targeted mutation 1, Joseph M Miano
• MGI ID: MGI:3849559
• Synonyms: Myocd-Cre
• Gene: Myocd Location: Chr11:65067387-65160815 bp, - strand Genetic Position: Chr11, 40.42 cM
• Alliance: Myocd^tm1(cre)Jomm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149882
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Myocd^tm1(cre)Jomm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myocd (MGI:2137495)

• Mutation details: The coding region of Myocd exon 1 was replaced via homologous recombination with a construct containing a cre recombinase sequence and a Frt-flanked neo cassette, such that the endogenous Myocd promoter drove expression of cre. The neo cassette was subsequently removed by breeding the mice with Flpe trangenic animals. (J:149882)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myocd (mouse) Summary of all recombinase alleles driven by Myocd. Comparative matrix view of recombinase activities Alliance mouse Myocd gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myocd Mutation: 53 strains or lines available

References

• Original: J:149882 Long X, et al., Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16570-5
• All: 5 reference(s)