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Myocdtm1(cre)Jomm
Targeted Allele Detail
Nomenclature
Symbol: Myocdtm1(cre)Jomm
Name: myocardin; targeted mutation 1, Joseph M Miano
MGI ID: MGI:3849559
Synonyms: Myocd-Cre
Gene: Myocd  Location: Chr11:65176561-65269989 bp, - strand  Genetic Position: Chr11, 40.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149882
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region of Myocd exon 1 was replaced via homologous recombination with a construct containing a cre recombinase sequence and a Frt-flanked neo cassette, such that the endogenous Myocd promoter drove expression of cre. The neo cassette was subsequently removed by breeding the mice with Flpe trangenic animals. (J:149882)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myocd     Summary of all recombinase alleles driven by Myocd. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myocd Mutation:  35 strains or lines available
References
Original:  J:149882 Long X, et al., Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16570-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory