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Pou4f3tm1.1Nat
Targeted Allele Detail
Nomenclature
Symbol: Pou4f3tm1.1Nat
Name: POU domain, class 4, transcription factor 3; targeted mutation 1.1, Jeremy Nathans
MGI ID: MGI:3849065
Synonyms: Brn3c-CKOAP
Gene: Pou4f3  Location: Chr18:42527662-42529158 bp, + strand  Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177259
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was introduced to the 5' UTR (50 bp upstream of the ATG start codon), and three repeats of the SV40 early terminator were placed in the 3' UTR (300 bp downstream of the stop codon) along with a second loxP site, the human placental alkaline phosphatase (AP) gene, and an FRT-flanked neomycin resistance gene. The targeting vector was introduced to 129-derived embryonic stem cells. The neomycin cassette was excised with a germline FLP recombinase. (J:177259)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou4f3 Mutation:  15 strains or lines available
References
Original:  J:177259 Badea T, et al., Creation of a conditional knock-in alkaline phosphatase reporter in Pou4f3. MGI Direct Data Submission. 2011;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory