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Aqp4tm1.1Tsna
Targeted Allele Detail
Nomenclature
Symbol: Aqp4tm1.1Tsna
Name: aquaporin 4; targeted mutation 1.1, Tsutomu Nakada
MGI ID: MGI:3848919
Gene: Aqp4  Location: Chr18:15522553-15544039 bp, - strand  Genetic Position: Chr18, 8.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149545
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by immunohistochemistry. (J:149545)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aqp4 Mutation:  32 strains or lines available
References
Original:  J:149545 Kitaura H, et al., Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res. 2009 Jun;64(2):208-12
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory