Aqp4^tm1.1Tsna
Targeted Allele Detail

Summary

• Symbol: Aqp4^tm1.1Tsna
• Name: aquaporin 4; targeted mutation 1.1, Tsutomu Nakada
• MGI ID: MGI:3848919
• Gene: Aqp4 Location: Chr18:15522553-15544039 bp, - strand Genetic Position: Chr18, 8.74 cM
• Alliance: Aqp4^tm1.1Tsna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149545
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by immunohistochemistry. (J:149545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aqp4 Mutation: 42 strains or lines available

References

• Original: J:149545 Kitaura H, et al., Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res. 2009 Jun;64(2):208-12
• All: 4 reference(s)