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Targeted Allele Detail
Symbol: Plrg1tm2Jcbr
Name: pleiotropic regulator 1; targeted mutation 2, Jens Bruning
MGI ID: MGI:3848231
Synonyms: PLRG1FL, PLRG1flox
Gene: Plrg1  Location: Chr3:83055522-83072355 bp, + strand  Genetic Position: Chr3, 36.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:149153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. The neo cassette was removed by frt mediated recombination. (J:149153)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plrg1 Mutation:  10 strains or lines available
Original:  J:149153 Kleinridders A, et al., PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol. 2009 Jun;29(11):3173-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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