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RhoTvrm1
Chemically induced Allele Detail
Nomenclature
Symbol: RhoTvrm1
Name: rhodopsin; translational research vision model 1
MGI ID: MGI:3845396
Gene: Rho  Location: Chr6:115931748-115940036 bp, + strand  Genetic Position: Chr6, 53.72 cM
Photoreceptor degeneration in RhoTvrm4/Rho+ and RhoTvrm1/Rho+ mutants is rapidly induced by exposure to bright light

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA missense mutation changes amino acid 102, tyrosine (TAC), to histidine (CAC) .Tyr-102 is in the first extracellular loop of Rho and is also conserved among species, including human, primate, cat, dog, and rat. (J:159523)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rho Mutation:  32 strains or lines available
References
Original:  J:159523 Budzynski E, et al., Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 7;285(19):14521-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory