Rho^Tvrm1
Chemically induced Allele Detail

Summary

• Symbol: Rho^Tvrm1
• Name: rhodopsin; translational research vision model 1
• MGI ID: MGI:3845396
• Gene: Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
• Alliance: Rho^Tvrm1 page

Photoreceptor degeneration in Rho^Tvrm4/Rho⁺ and Rho^Tvrm1/Rho⁺ mutants is rapidly induced by exposure to bright light

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A missense mutation changes amino acid 102, tyrosine (TAC), to histidine (CAC) .Tyr-102 is in the first extracellular loop of Rho and is also conserved among species, including human, primate, cat, dog, and rat. (J:159523)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rho Mutation: 48 strains or lines available

References

• Original: J:159523 Budzynski E, et al., Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 7;285(19):14521-33
• All: 2 reference(s)