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Six2tm3(EGFP/cre/ERT2)Amc
Targeted Allele Detail
Nomenclature
Symbol: Six2tm3(EGFP/cre/ERT2)Amc
Name: sine oculis-related homeobox 2; targeted mutation 3, Andrew P McMahon
MGI ID: MGI:3845222
Synonyms: Six2eGFPCreERT2, Six2-eGFPCreERT2, Six2-eGFPCreERT2, Six2-eGFP-creTg, Six2GCE, Six2-GCE
Gene: Six2  Location: Chr17:85684277-85688274 bp, - strand  Genetic Position: Chr17, 55.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148455
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129/Sv x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe targeting vector was designed to insert an eGFPCreERT2 (GCE) fusion protein coding sequence and frt-flanked PGKneobpA selection cassette into the initiation codon of the Six2 (sine oculis-related homeobox 2 homolog (Drosophila)) targeted gene. (J:148455)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Six2     Summary of all recombinase alleles driven by Six2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Six2 Mutation:  8 strains or lines available
References
Original:  J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory