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Hdac2tm1.2Rdp
Targeted Allele Detail
Nomenclature
Symbol: Hdac2tm1.2Rdp
Name: histone deacetylase 2; targeted mutation 1.2, Ronald DePinho
MGI ID: MGI:3844984
Synonyms: HDAC2KO
Gene: Hdac2  Location: Chr10:36974544-37001889 bp, + strand  Genetic Position: Chr10, 19.44 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148391
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted upstream of exon 5 and downstream of exon 6. Mice carrying this allele were crossed with mice expressing cre recombinase in the germline. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote brain extracts. The same analysis showed that expression of related Hdac1 protein was upregulated. (J:148391)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:  21 strains or lines available
References
Original:  J:148391 Guan JS, et al., HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 7;459(7243):55-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory