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Targeted Allele Detail
Symbol: Myh9tm1.1Gac
Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Christian Gachet
MGI ID: MGI:3843980
Synonyms: Myh9flox, MYH9Flx
Gene: Myh9  Location: Chr15:77644787-77726375 bp, - strand  Genetic Position: Chr15, 36.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:148233
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1, and a floxed neo cassette was inserted downstream of exon 1. Transient expression in ES cells removed the neo cassette leaving exon 1 floxed. (J:148233)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Myh9 Mutation:  226 strains or lines available
Original:  J:148233 Leon C, et al., Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood. 2007 Nov 1;110(9):3183-91
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory