Hcst^tm1.1Dnax
Targeted Allele Detail

Summary

• Symbol: Hcst^tm1.1Dnax
• Name: hematopoietic cell signal transducer; targeted mutation 1.1, DNAX Research Institute of Cellular and Molecular Biology
• MGI ID: MGI:3843505
• Gene: Hcst Location: Chr7:30117137-30119279 bp, - strand Genetic Position: Chr7, 17.45 cM
• Alliance: Hcst^tm1.1Dnax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a floxed neo cassette. Transient cre expression in ES cells removes the neo cassette. The absence of transcript expression was confirmed by RT-PCR on lymphoid tissue extracts. (J:148086)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcst Mutation: 9 strains or lines available

References

• Original: J:100453 Ogasawara K, et al., Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat Immunol. 2005 Sep;6(9):938-45
• All: 6 reference(s)