Tlr9^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^M5Btlr
• Name: toll-like receptor 9; mutation 5, Bruce Beutler
• MGI ID: MGI:3843064
• Synonyms: CpG6, Tlr9^CpG6, unmethylated CpG-oligodeoxynucleotide unresponsive 6
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered in an in vivo CpG challenge screen of progeny of an ENU mutagenized male mouse, comprises a G to A transition at nucleotide position 3188, in the second and last exon of the gene, that results in replacement of glycine by arginine at amino acid position 1028 of the receptor protein (Q1028R). (J:86521, J:147856)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 65 strains or lines available

References

• Original: J:147856 Blasius AL, et al., Record for "CpG6", updated April 29, 2009. MGI Direct Data Submission. 2009
• All: 4 reference(s)