Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M5Btlr mutation
(1 available);
any
Tlr9 mutation
(65 available)
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immune system
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• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides
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• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M5Btlr mutation
(1 available);
any
Tlr9 mutation
(65 available)
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immune system
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• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides
• responses of mutant macrophages to other Toll-like receptor (TLR) ligands are normal
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• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides
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hematopoietic system
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• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides
• responses of mutant macrophages to other Toll-like receptor (TLR) ligands are normal
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Analysis Tools