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Tg(KRT5-Akt1*)Jmpa
Transgene Detail
Nomenclature
Symbol: Tg(KRT5-Akt1*)Jmpa
Name: transgene insertion, Jesus M Paramio
MGI ID: MGI:3842829
Synonyms: BK5myrAkt
Transgene: Tg(KRT5-Akt1*)Jmpa  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT5-Akt1*)Jmpa expresses 1 gene
 
Mutation detailsThe bovine promoter was used to drive epithelial-specific expression of a myristoylated mouse Akt1. Two lines were created (L60 and L84). (J:127302)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127302 Segrelles C, et al., Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res. 2007 Nov 15;67(22):10879-88
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory