Del(2Hoxd12-Hoxd13)41Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd12-Hoxd13)41Ddu
• Name: deletion, Chr 2, Denis Duboule 41
• MGI ID: MGI:3840818
• Synonyms: Del41Ddu, Hoxd^1213lac, HoxD^{(12delta13)lac}
• Gene: Del(2Hoxd12-Hoxd13)41Ddu Location: Chr2:74498654-74508049 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47366
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(2Hoxd12-Hoxd13)41Ddu involves 2 genes/genome features (Hoxd13, Hoxd12) View all
• Mutation details: Germ line, cre mediated recombination between Hoxd12^tm2Ddu and Hoxd13^tm2Ddu maintained in cis results in the deletion of the 3' end of exon 1 Hoxd12^tm2Ddu through the lacZ insertion in exon 1 Hoxd12^tm2Ddu. The lacZ cassette inserted into Hoxd13 is retained. In situ hybrizidation confirmed expression of the fusion transcript in a similar pattern observed for Hoxd11. (J:47366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd12-Hoxd13)41Ddu Mutation: 0 strains or lines available

References

• Original: J:47366 Kondo T, et al., Control of colinearity in AbdB genes of the mouse HoxD complex. Mol Cell. 1998 Jan;1(2):289-300
• All: 2 reference(s)